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Epigenetics & Chromatin

Recombinant Nucleosomes

custom designed recombinant nucleosomes

ReNucs™ are Recombinant Nucleosomes designed to contain specific histone post-translational modifications, amino acid substitutions and other modifications, delivering the most biologically relevant and powerful tools for development of novel drug targets and precision medicine. Developed in our own labs, each recombinant nucleosome is comprised of octamers of designer-modified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Active Motif currently offers the widest portfolio of pre-assembled Mononucleosome and Polynucleosome proteins available – and as the Epigenetics Experts, we continue to release newly designed ReNucs every month.

All of our recombinant nucleosomes are available in small scale and bulk quantities. For a bulk order quote, contact us.

View our flyer, for a complete listing of Recombinant Nucleosomes,
Mononucleosomes, Polynucleosomes, and related proteins.

HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates.
HMT activity assay comparing recombinant nucleosomes and histone octamers as substrates (click image to enlarge).
 

Whatever your application, ReNucs™ recombinant nucleosome proteins offer the most biologically relevant substrates when compared to histone proteins alone or synthetic peptides:

  1. Mononucleosomes and Polynucleosomes available
  2. Biotinylated nucleosomes for protein-nucleosome interaction studies and pull-down assays
  3. Post-translational modifications – designed for optimal physiological relevance
  4. Amino acid mutations – as published, these ReNucs mostly closely mimic naturally occurring nucleosomes in your own experimental design.
  5. Coming Soon – Quadra-modified ReNucs, including four post-translational modifications in each nucleosome
 
Name Expressed In Format Plain Name Cat No. Price  
Recombinant Polynucleosomes (H3.1) E. coli 20 µg Recombinant Polynucleosomes (H3.1) 31466 $395 Buy Now
Recombinant Polynucleosomes (H3.3) E. coli 20 µg Recombinant Polynucleosomes (H3.3) 31468 $395 Buy Now
Recombinant Mononucleosomes (H3.1) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H3.1) - biotinylated 31467 $395 Buy Now
Recombinant Mononucleosomes (H3.3) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H3.3) - biotinylated 31469 $395 Buy Now
Recombinant Polynucleosomes H3.3 (K27M) E. coli 20 µg Recombinant Polynucleosomes H3.3 (K27M) 31562 $395 Buy Now
Recombinant Polynucleosomes H3.3 (G34L) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34L) 31558 $395 Buy Now
Recombinant Polynucleosomes H3.3 (G34R) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34R) 31559 $395 Buy Now
Recombinant Polynucleosomes H3.3 (G34V) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34V) 31560 $395 Buy Now
Recombinant Polynucleosomes H3.3 (G34W) E. coli 20 µg Recombinant Polynucleosomes H3.3 (G34W) 31561 $395 Buy Now
Recombinant Polynucleosomes H3.3 (K36M) E. coli 20 µg Recombinant Polynucleosomes H3.3 (K36M) 31563 $395 Buy Now
Recombinant Mononucleosomes (H2A.Bbd) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H2A.Bbd) - biotinylated 31556 $415 Buy Now
Recombinant Mononucleosomes (TH2B) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (TH2B) - biotinylated 31557 $415 Buy Now
Recombinant Mononucleosomes (H2A.X) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H2A.X) - biotinylated 31582 $415 Buy Now
Recombinant Mononucleosomes (H2A.Z) - biotinylated E. coli 20 µg Recombinant Mononucleosomes (H2A.Z) - biotinylated 31583 $415 Buy Now
Recombinant Mononucleosomes H3K4me3 (EPL) - biotinylated E. coli 20 µg Recombinant Mononucleosomes H3K4me3 (EPL) - biotinylated 31584 $445 Buy Now
Recombinant Mononucleosomes H3K4me1 (EPL) - biotinylated E. coli 20 µg Recombinant Mononucleosomes H3K4me1 (EPL) - biotinylated 31585 $445 Buy Now
Recombinant Mononucleosomes H3K9me3 (EPL) E. coli 20 µg Recombinant Mononucleosomes H3K9me3 (EPL) 31586 $415 Buy Now
Recombinant Histone Octamer (H3.1) E. coli 100 µg Recombinant Histone Octamer (H3.1) 31470 $395 Buy Now
Recombinant Histone Octamer (H3.1) - biotinylated E. coli 50 µg Recombinant Histone Octamer (H3.1) - biotinylated 31471 $470 Buy Now
Recombinant Histone Octamer (H3.3) E. coli 100 µg Recombinant Histone Octamer (H3.3) 31472 $395 Buy Now
Recombinant Histone Octamer (H3.3) - biotinylated E. coli 50 µg Recombinant Histone Octamer (H3.3) - biotinylated 31473 $470 Buy Now